Difference and Factor Associated with Interferon Gamma Level in Pulmonary Tuberculosis Patients and Healthy Control

BACKGROUND : Interferon-gamma (INF-γ) is an important cytokine in the immune response against Mycobacterium tuberculosis. activates macrophage to kill intracellular mycobacterium. AIM: The aim of this study determine difference plasma INF-γ level pulmonary tuberculosis (PTB) patients compared a healthy control and factors associated with interferon-gamma level. METHODS: This case–control study. Fifty subjects were selected, including 25 new PTB positive sputum smear, (non TB patients) no symptoms tuberculosis, normal chest X-Ray history previous concentration was determined by ELISA technique. Data analyzed independent t-test results statistically significant at p < 0.05. RESULTS: significantly higher (p = 0.024). Mean ± SD interferon gamma 317.2 201.97 pg/ml 213.5 86.43 control. Acid fast bacilli (AFB) positivity 0.001). Interferon AFB 1+ 503.22 146.15 pg/ml, 2+ 337 81.61 3+ 88.27 51.32 pg/ml. Sex, body mass index (BMI), age not CONCLUSIONS: than BMI, patients.